Identification and determination of material properties for porohyperelastic analysis of large arteries

作     者：Simon, BR Kaufmann, MV McAfee, MA Baldwin, AL Wilson, LM 

作者机构：Univ Arizona Dept Aerosp & Mech Engn Tucson AZ 85721 USA Univ Arizona Dept Physiol Tucson AZ 85721 USA 

出 版 物：《JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME》 (美国机械工程师学会汇刊：生物机械工程学杂志)

年 卷 期：1998年第120卷第2期

页      面：188-194页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：主动脉 胸/解剖学和组织学 主动脉 胸/生理学 血流速度 血压 计算机模拟 弹性 内皮 血管/解剖学和组织学 内皮 血管/生理学 有限元分析 血液流变学 模型 心血管 通透性 多孔性 应力 物理 血管内膜/解剖学和组织学 血管内膜/生理学 血管中膜/解剖学和组织学 血管中膜/生理学 水 动物 兔 

摘      要：A porohyperelastic (PHE) material model is described and the theoretical framework presented that allows identification of the necessary material properties functions for soft arterial tissues. A generalized Fung form is proposed for the PHE constitutive law in which the two fundamental Lagrangian material properties are the effective strain energy density function, W-e, and the hydraulic permeability, (k) over tilde(ij). The PHE model is based on isotropic forms using W-e = U-e(phi) = 1/2C(0)(e(phi) - 1) and the radial component of permeability, (k) over tilde(RR) = (k) over tilde(RR)(phi), with phi = C-1((I) over bar - 3) + C-2 ((I) over bar(2) - 3) + K (J - 1)(2). The methods for determination of these material properties are illustrated using experimental data from in situ rabbit aortas. Three experiments are described to determine parameters in U-e and (k) over tilde(RR) for the intima and media of the aortas, i.e., (I) undrained tests to determine C-0, C-1 , and C-2 ;(2) drained tests to determine K ;and (3) steady-state pressurization tests of intact and de-endothelialized vessels to determine intimal and medial permeability (adventitia removed in these models). Data-reduction procedures are presented that allow determination of (k) over tilde(RR) for the intima and media and U-e for the media using experimental darn. The effectiveness and accuracy of these procedures are studied using input data from finite element models generated with the ABAQUS program. The isotropic theory and data-reduction methods give good approximations for the PHE properties of in situ aortas. These methods can be extended to include arterial tissue remodeling and anisotropic behavior when appropriate experimental data are available.