Bending and Base-Stacking Interactions in Double-Stranded DNA

作     者：Zhou Haijun Zhang Yang Ou-Yang Zhong-can 

作者机构：Institute of Theoretical Physics Academia Sinica P.O. Box 2735 Beijing 100080 China State Key Laboratory of Scientific and Engineering Computing Beijing 100080 China Center for Advanced Study Tsinghua University Beijing 100084 China 

出 版 物：《Physical Review Letters》 (Phys Rev Lett)

年 卷 期：1999年第82卷第22期

页      面：4560-4560页

核心收录：

学科分类：07[理学] 0702[理学-物理学] 

主　　题：.parameter negatively extensibility supercoiling backbones relaxed supercoiled dsDNA Ou-Yang torsionally base-stacking folding angle steric effects nucleotide base 

摘      要：An elastic model for double-stranded polymers is constructed to study the recently observed DNA entropic elasticity, cooperative extensibility, and supercoiling property. With the introduction of a new structural parameter (the folding angle ϕ), bending deformations of sugar-phosphate backbones, steric effects of nucleotide base pairs, and base-stacking interactions are considered. The comprehensive agreements between theory and experiments both on torsionally relaxed DNA and on negatively supercoiled DNA strongly indicate that base-stacking interactions, although short-ranged in nature, dominate the elasticity of DNA and, hence, are of vital biological significance.