Differential X-ray phase contrast tomography of Alzheimer plaques in mouse models: perspectives for drug development and clinical imaging techniques

作     者：Pinzer, B. R. Cacquevel, M. Modregger, P. Thuering, T. Stampanoni, M. 

作者机构：Paul Scherrer Inst Swiss Light Source CH-5232 Villigen Switzerland Ecole Polytech Fed Lausanne Brain Mind Inst CH-1015 Lausanne Switzerland Univ Lausanne Fac Biol & Med CH-1015 Lausanne Switzerland ETH Inst Biomed Engn CH-8092 Zurich Switzerland 

出 版 物：《JOURNAL OF INSTRUMENTATION》 (仪表制造杂志)

年 卷 期：2013年第8卷第5期

页      面：C05005-C05005页

核心收录：

学科分类：08[工学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 081102[工学-检测技术与自动化装置] 0811[工学-控制科学与工程] 

主　　题：Computerized Tomography (CT) and Computed Radiography (CR) Instrumentation for synchrotron radiation accelerators Medical-image reconstruction methods and algorithms computer-aided so 

摘      要：Alzheimer s disease (AD) is a looming threat on an ever-ageing population, with devastating effects on the human intellect. A particular characteristic lesion - the extracellular amyloid plaque - accumulates in the brain of AD patients during the course of the disease, and could therefore be used to monitor the progression of the disease, years before the first neurological symptoms appear. In addition, strategies for drug intervention in AD are often based on amyloid reduction, since amyloid plaques are hypothesized to be involved in a chain of reactions leading to the death of neurons. Developments in both fields would benefit from a microscopic technique that is capable of single plaque imaging, ideally in 3D. While such a non-destructive, single-plaque imaging technique does not yet exist for humans, it has been recently shown that synchrotron based differential X-ray phase contrast imaging can be used to visualize individual plaques at m m resolution in mouse models of AD ex-vivo. This method, which relies on a grating interferometer to measure refraction angles induced by fluctuations in the refractive index, yields a precise three-dimensional distribution of single plaques. These data could not only improve the understanding of the evolution of AD or the effectiveness of drugs, but could also help to improve reliable markers for current and future non-invasive clinical imaging techniques. In particular, validation of PET markers with small animal models could be rapidly carried out by co-registration of PET and DPC signals.