An Integrated Sequence-Structure Database incorporating matching mRNA sequence, amino acid sequence and protein three-dimensional structure data

作     者：Adzhubei, IA Adzhubei, AA Neidle, S 

作者机构：Inst Canc Res CRC Biomol Struct Unit Surrey SM2 5NG England Moscow MV Lomonosov State Univ Fac Biol Dept Mol Biol Moscow 119899 Russia 

出 版 物：《NUCLEIC ACIDS RESEARCH》 (Nucleic Acids Res.)

年 卷 期：1998年第26卷第1期

页      面：327-331页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Cancer Research Campaign, (SP13848SN) Florida State University, FSU Royal Society Russian Foundation for Basic Research, РФФИ 

主　　题：Databases Factual Nucleic Acid Conformation Protein Conformation RNA Messenger 数据库 事实型 核酸构象 蛋白质构象 信使 Nucleic Acid Conformation Amino Acid Sequence messengers NR4A2 protein, human Protein Conformation RNA Coding Sequence Database Nucleotides 

摘      要：We have constructed a non-homologous database, termed the Integrated Sequence-Structure Database (ISSD) which comprises the coding sequences of genes, amino acid sequences of the corresponding proteins, their secondary structure and phi, psi angles assignments, and polypeptide backbone coordinates, Each protein entry in the database holds the alignment of nucleotide sequence, amino acid sequence and the PDB three-dimensional structure data, The nucleotide and amino acid sequences for each entry are selected on the basis of exact matches of the source organism and cell environment, The current version 1.0 of ISSD is available on the WWW at http://***/issd/ and includes 107 non-homologous mammalian proteins, of which 80 are human proteins, The database has been used by us for the analysis of synonymous codon usage patterns in mRNA sequences showing their correlation with the three-dimensional structure features in the encoded proteins, Possible ISSD applications include optimisation of protein expression, improvement of the protein structure prediction accuracy, and analysis of evolutionary aspects of the nucleotide sequence-protein structure relationship.