Etiologic heterogeneity among non-hodgkin lymphoma subtypes: The interLymph non-hodgkin lymphoma subtypes project

作     者：Morton, Lindsay M. Slager, Susan L. Cerhan, James R. Wang, Sophia S. Vajdic, Claire M. Skibola, Christine F. Bracci, Paige M. de Sanjosé, Silvia Smedby, Karin E. Chiu, Brian C. H. Zhang, Yawei Mbulaiteye, Sam M. Monnereau, Alain Turner, Jennifer J. Clavel, Jacqueline Adami, Hans-Olov Chang, Ellen T. Glimelius, Bengt Hjalgrim, Henrik Melbye, Mads Crosignani, Paolo di Lollo, Simonetta Miligi, Lucia Nanni, Oriana Ramazzotti, Valerio Rodella, Stefania Costantini, Adele Seniori Stagnaro, Emanuele Tumino, Rosario Vindigni, Carla Vineis, Paolo Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Cocco, Pierluigi Foretova, Lenka Maynadié, Marc Nieters, Alexandra Staines, Anthony Colt, Joanne S. Cozen, Wendy Davis, Scott de Roos, Anneclaire J. Hartge, Patricia Rothman, Nathaniel Severson, Richard K. Holly, Elizabeth A. Call, Timothy G. Feldman, Andrew L. Habermann, Thomas M. Liebow, Mark Blair, Aaron Cantor, Kenneth P. Kane, Eleanor V. Lightfoot, Tracy Roman, Eve Smith, Alex Brooks-Wilson, Angela Connors, Joseph M. Gascoyne, Randy D. Spinelli, John J. Armstrong, Bruce K. Kricker, Anne Holford, Theodore R. Lan, Qing Zheng, Tongzhang Orsi, Laurent Dal Maso, Luigino Franceschi, Silvia La Vecchia, Carlo Negri, Eva Serraino, Diego Bernstein, Leslie Levine, Alexandra Friedberg, Jonathan W. Kelly, Jennifer L. Berndt, Sonja I. Birmann, Brenda M. Clarke, Christina A. Flowers, Christopher R. Foran, James M. Kadin, Marshall E. Paltiel, Ora Weisenburger, Dennis D. Linet, Martha S. Sampson, Joshua N. 

作者机构：Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD United States Department of Health Sciences Research College of Medicine Mayo Clinic Rochester MN United States Department of Cancer Etiology City of Hope Beckman Research Institute Duarte CA United States Prince of Wales Clinical School University of New South Wales Sydney Australia Department of Epidemiology Comprehensive Cancer Center University of Alabama Birmingham AL United States Department of Epidemiology and Biostatistics School of Medicine University of California San Francisco San Francisco CA United States Unit of Infections and Cancer (UNIC) Cancer Epidemiology Research Programme Institut Català d' Oncologia IDIBELL L'Hospitalet de Llobregat Barcelona Spain CIBER de Epidemiología y Salud Pública (CIBERESP) Barcelona Spain Unit of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Karolinska University Hospital Stockholm Sweden Department of Health Studies University of Chicago Chicago IL United States Department of Environmental Health Sciences Yale School of Public Health New Haven CT United States INSERM Centre for Research in Epidemiology and Population Health (CESP) U1018 Environmental Epidemiology of Cancer Group Villejuif France Univ Paris Sud UMRS 1018 Villejuif France Registry of Hematological Malignancies in Gironde Bergonié Institute 33076 Bordeaux France Department of Histopathology Douglass Hanly Moir Pathology Macquarie Park Australia The Australian School of Advanced Medicine Macquarie University Sydney Australia Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden Department of Epidemiology Harvard School of Public Health Boston MA United States Health Sciences Practice Exponent Inc. Menlo Park CA United States Department of Health Research and Policy Stanford University School of Medicine Stanford CA United States Department of Oncology and Pathology Karolinska Institutet Stockholm Sweden Department of Radiology Oncology and Radiation Science Uppsala University Uppsala Sweden Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark Epidemiology Unit Fondazione IRCCS Istituto dei Tumori Milan Italy Department of Surgery and Translational Medicine University of Florence Florence Italy Unit of Occupational and Environmental Epidemiology Cancer Prevention and Research Institute ISPO Florence Italy Biostatistics and Clinical Trials Unit- IRCCS IRST Meldola Italy Epidemiology Unit Regina Elena National Cancer Institute Rome Italy Healthcare Development and Evaluation Unit Agency for Health and Social Care Bologna Italy Unit of Epidemiology Biostatistics and Clinical Trials IRCCS AOU San Martino-IST Genoa Italy Cancer Registry and Histopathology Unit 'Civile - M.P. Arezzo' Hospital ASP Ragusa Ragusa Italy Pathology Unit Azienda Ospedaliera Universitaria Senese Siena Italy Cancer Epidemiology Unit Imperial College London London United Kingdom Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY United States International Agency for Research on Cancer Lyon France Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari Cagliari Italy Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic Biological Hematology Unit CRB Ferdinand Cabanne Universitary Hospital of Dijon Dijon France EA4184 University of Burgundy Dijon France Center for Chronic Immunodeficiency (CCI) University Medical Center Freiburg Freiburg Germany School of Nursing and Human Sciences Dublin City University Dublin Ireland Department of Preventive Medicine and Pathology Norris Comprehensive Cancer Center USC Keck School of Medicine University of Southern California Los Angeles CA United States Fred Hutchinson Cancer Research Center Seattle WA United States School of Public Health University of Washington Seattle WA United States Department of Environmental and Occupational Health Drexel University School of Public Health Philadelphia PA United States Department of Family Medicine and Public Health Sciences Wayne State University Detroit MI United States Division of Hematology College of Medicine Mayo Clinic Rochester MN United States Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN United States Divison of General Internal Medicine College of Medicine Mayo Clinic Rochester MN United States Epidemiology and Cancer Statistics Group Department of Health Sciences University of York York United Kingdom Genome Sciences Centre BC Cancer Agency Vancouver BC Canada Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby BC Canada Centre for Lymphoid Cancer BC Cancer Agency Vancouver BC Canada Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada Cancer Control Research BC Cancer Agency Vancouver BC Canada School of Population and Public Health University of British Columbia Vancouver BC Canada Sydney School of Public Health University of Sydney Sydney Australia Department of Biostatistics Yale School of Public Health New Haven CT United States Unit of Epidemiology and Biostatistics Centro di Riferimento Oncologico IRCCS Aviano Italy Department of Epidemiology IRCCS Istituto di Ricerche Farmacologiche Mario Negri Milan Italy Department of Clinical Sciences and Community Health University of Milan Milan Italy James P. Wilmot Cancer Center University of Rochester Rochester NY United States Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA United States Cancer Prevention Institute of California Fremont CA United States Winship Cancer Institute Emory University Atlanta GA United States Department of Cancer Biology Mayo Clinic Cancer Center Jacksonville FL United States Department of Dermatology Boston University Boston MA United States Roger Williams Medical Center Providence RI United States Hadassah-Hebrew University Jerusalem Israel Department of Pathology City of Hope National Medical Center Duarte CA United States 

出 版 物：《Journal of the National Cancer Institute - Monographs》 (J. Natl. Cancer Inst. Monogr.)

年 卷 期：2014年第2014卷第48期

页      面：130-144页

基　　金：Cancer Council NSW Michael Smith Foundation for Health Research Canadian Cancer Society American Association for Cancer Research, AACR National Cancer Institute, NCI, (R01CA050850, P30CA033572, R01CA062006, R03CA143947, R03CA132153, R01CA100555, R21CA165923, P50CA130805, R03CA150037, R03CA125831, R01CA092153, R01CA122663, R01CA154643, K23CA102216, R01CA045614, R01CA051086, U01CA118444, R01CA149445, P30CA016359, ZIACP010170, R01CA104682, P50CA097274, R13CA159842, R01CA087014) National Cancer Institute, NCI National Center for Advancing Translational Sciences, NCATS, (UL1TR000042, UL1TR000142, UL1TR000135, UL1TR000430) National Center for Advancing Translational Sciences, NCATS National Heart, Lung, and Blood Institute, NHLBI, (T32HL007152) National Heart, Lung, and Blood Institute, NHLBI Medical Research Council, MRC, (ID990920) Medical Research Council, MRC Lymphoma Research Foundation, (164738) Lymphoma Research Foundation National Center for Research Resources, NCRR, (UL 1 RR024160) National Center for Research Resources, NCRR National Cancer Institute, NCI, (N01-PC-67008, N01-PC-65064, U01 CA118444, RO1CA122663, N02-PC-71105, R03CA132153, R01 CA92153, RO1CA154643-01A1, P50 CA130805, N01-CP-95618, R01CA45614, R01CA104682, R01CA100555) National Cancer Institute, NCI National Institutes of Health, NIH, (NO1-CO-12400, R01 CA14690, T32 HL007152, K23 CA102216, P50 CA97274, N01-PC-67010, R01CA087014, R13 CA159842 01, R01 CA92153-S1, N01-CP-ES-11027, R03CA125831, N01-PC-67009, R01 CA50850, 5R01 CA69669-02) National Institutes of Health, NIH European Commission, EC, (FOOD-CT-2006-023103, QLK4-CT-2000-00422) European Commission, EC National Center for Research Resources, NCRR, (UL1RR024160) National Center for Research Resources, NCRR National Health and Medical Research Council, NHMRC, (990920) National Health and Medical Research Council, NHMRC American Institute for Cancer Research, AICR, (99B083) American Institute for Cancer Research, AICR 

摘      要：Background: Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes. Methods: We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (Q value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based P values (PNODE). Results: Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (PNODE -4), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (PNODE -4). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and decreased r