Experimental microgyri disrupt the barrel field pattern in rat somatosensory cortex

作     者：Jacobs, KM Mogensen, M Warren, E Prince, DA 

作者机构：Stanford Univ Med Ctr Dept Neurol & Neurol Sci Stanford CA 94305 USA 

出 版 物：《CEREBRAL CORTEX》 (大脑皮层)

年 卷 期：1999年第9卷第7期

页      面：733-744页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：NINDS NIH HHS [NS09806  NS12151] Funding Source: Medline 

主　　题：年龄因素 动物 新生 脑图 去神经支配 疾病模型 动物 电生理学 癫痫/病理学 癫痫/病理生理学 冷冻 大鼠 Sprague-Dawley 躯体感觉皮质/生长和发育 躯体感觉皮质/病理学 躯体感觉皮质/病理生理学 触须/神经支配 触须/生理学 动物 大鼠 

摘      要：Transcranial freeze lesions in neonatal rat pups produce microgyri and adjacent epileptogenic regions of neocortex that can be used to model human polymicrogyria. The hypothesis that the presence of microgyri is associated with abnormal cortical organization occurring within as well as adjacent to the microgyri was tested by creating microgyri within the face representation of somatosensory cortex. Microgyri were associated with a widespread disruption of the stereotypic whisker barrel field pattern delineated with cytochrome oxidase (CO) staining. CO-stained patches resembling barrel hollows were absent within the microgyrus, and were abnormally shaped and distributed outside of the microgyrus. Adjacent Nissl- or acetylcholinesterase-stained sections demonstrated that both cell clusters and thalamocortical afferents contributed to the abnormally organized paramicrogyral zone identified in GO-stained sections. Field potential recordings showed that this region of heavy CO staining corresponded to the epileptogenic zone adjacent to the microgyrus. Results support our hypothesis that the epileptogenic paramicrogyral zone develops an abnormal organization of cell clusters and thalamocortical projections that could contribute to epileptogenesis in the paramicrogyral zone.