The effectiveness of two oral contraceptives in suppressing plasma androstenedione, testosterone, LH, and FSH, and in stimulating plasma testosterone-binding capacity in hirsute women

作     者：Givens, James R. Andersen, Richard N. Wiser, Winfred L. Umstot, Edward S. Fish, Stewart A. 

作者机构：Division of Reproductive Medicine Department of Obstetrics and Gynecology University of Tennessee Center For the Health Sciences Memphis TN United States 

出 版 物：《American Journal of Obstetrics and Gynecology》 (Am. J. Obstet. Gynecol.)

年 卷 期：1976年第124卷第4期

页      面：333-339页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：Department of Obstetrics and Gynecology, University of Tennessee University of Tennessee Clinical Research Center, (RR-21 1) National Institutes of Health, NIH U.S. Public Health Service, USPHS, (HL-09495, ME-000-79) 

摘      要：The effectiveness of two oral contraceptives in suppressing plasma androstenedione (A), testosterone (T), LH, and FSH and in stimulating testosterone-estradiol-binding globulin TeBG) was evaluated in 39 hirsute women. Twenty-seven hirsute women received norethindrone 2 mg.-mestranol 0.1 mg. (Group I) and 12 received norgestrel 0.5 mg.-ethinyl estradiol 0.05 mg. (Group II). Hormone assays were performed before treatment and at the end of 3 weeks of therapy. Ninety per cent of the women in both groups had an elevated plasma A and/or T. During treatment, plasma A, T, LH, and FSH were significantly reduced in both groups (p 0.01). In Group II, 78 per cent of the women had a normal plasma A and T during treatment. In Group II, 83 per cent of the women had a normal A and T during treatment. There was a greater increase in TeBG in Group I (p 0.01). It is concluded that these two oral contraceptives effectively suppressed the hyperandrogenism of most of the hirsute women. © 1976.