The history of the CATH structural classification of protein domains

作     者：Sillitoe, Ian Dawson, Natalie Thornton, Janet Orengo, Christine 

作者机构：UCL London WC1E 6BT England 

出 版 物：《BIOCHIMIE》 (生物化学)

年 卷 期：2015年第119卷

页      面：209-217页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：BBSRC [BB/K020013/1] Funding Source: UKRI 

主　　题：Protein structure Structure classification 

摘      要：This article presents a historical review of the protein structure classification database CATH. Together with the SCOP database, CATH remains comprehensive and reasonably up-to-date with the now more than 100,000 protein structures in the PDB. We review the expansion of the CATH and SCOP resources to capture predicted domain structures in the genome sequence data and to provide information on the likely functions of proteins mediated by their constituent domains. The establishment of comprehensive function annotation resources has also meant that domain families can be functionally annotated allowing insights into functional divergence and evolution within protein families. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://***/licenses/by/4.0/).