木豆叶芪类提取物对雌激素缺乏性大鼠骨质丢失的影响

作     者：郑元元 杨京 陈迪华 孙兰 ZHENG Yuan-yuan;YANG Jing;CHEN Di-hua;SUN Lan

作者机构：中国医学科学院中国协和医科大学基础医学研究所北京100005 中国医学科学院中国协和医科大学药用植物研究所北京100094 

出 版 物：《药学学报》 (Acta Pharmaceutica Sinica)

年 卷 期：2007年第42卷第5期

页      面：562-565页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：国家自然科学基金资助项目(20172072) 

主　　题：木豆叶芪类提取物 去卵巢大鼠 骨质丢失 

摘      要：The Cajanus cajan *** a natural plant,which contains lots of potential active *** effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were *** experimental female rats were divided into 6 groups,i.e.,sham-operated rats,OVX rats,17β-estradiol（E2）-treated rats,sECC-treated rats with three dosages,50,100,and 200(mg·kg-1),*** weeks after the operation,different dosage of sECC,E2 or deionized water were given to the 6 groups of rats,respectively for another 8 weeks through ***,all rats were *** body weight and uterus wet weight were *** of serum E2,follicle stimulating hormone（FSH）,and luteinizing hormone（LH） were measured by *** morphology was observed by HE *** results showed that there were no changes of the uterine weight and serum E2 concentration in sECC-treated rats compared with OVX ***,the serum FSH and LH concentrations reduced by 11.5% and 15.2%（P0.05）,*** HE staining,it is found that the 60% of the femur structure had been significantly improved in OVX rats treated with 200 mg·kg-1 of *** trabeculae were thicker and larger than that of OVX *** is clear that sECC improved femoral morphological structure and decreased FSH and LH contents without affecting serum E2 level and uterine weight in OVX *** results suggested that sECC had potential action in treatment of postmenopausal osteoporosis.