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作者机构:Hebrew Univ Jerusalem Hadassah Med Ctr Agnes Ginges Ctr Neurogenet Fac MedDept Neurol Jerusalem Israel Hadassah Med Ctr Leslie & Michael Ctr Neurooncol Jerusalem Israel
出 版 物:《JOURNAL OF NEUROIMMUNOLOGY》 (神经免疫学杂志)
年 卷 期:2018年第324卷
页 面:81-89页
核心收录:
学科分类:1001[医学-基础医学(可授医学、理学学位)] 10[医学]
主 题:IL7 receptor alpha (IL7Ra) CD127 Neuromyelitis optica (NMO) Gene expression array T cells NF-kB
摘 要:Neuromyelitis optica (NMO) is a chronic inflammatory demyelinating autoimmune disease of the central nervous system that most commonly affects the optic nerves and spinal cord. To characterize the immunological pathways involved in NMO, whole blood RNA expression array was performed using Nanostring nCounter technology. Two major clusters of genes were found associated with NMO: T cell-associated genes and the TNF/NF-kB signaling pathway. Analysis of the genes within the first cluster confirmed significantly reduced expression of IL7Ra (CD127) in the peripheral blood of NMO patients vs that in healthy controls. IL7Ra upstream transcription factors and its downstream survival signaling pathway were also markedly reduced. In line with the essential role of IL7Ra in T cell maturation and survival, a significantly lower number of naive T cells, and reduced T cell survival signaling mediated by increased BID (BH3-interacting domain death agonist) expression and increased apoptosis was observed. Cumulatively, these findings indicate that the IL7Ra signaling pathway may play a role in the autoimmune process in NMO.