Selective vasopressin, angiotensin II, or dual receptor blockade with developing congestive heart failure

作     者：Clair, MJ King, MK Goldberg, AT Hendrick, JW Nisato, R Gay, DM Morrison, AE McElmurray, JH Krombach, RS Bond, BR Cazaubon, C Nisato, D Spinale, FG 

作者机构：Med Univ S Carolina Div Cardiothorac Surg Charleston SC 29425 USA Sanofi Synthelabo Cardiovasc Thrombosis Res Dept Montpellier France 

出 版 物：《JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 (药理学与实验治疗学杂志)

年 卷 期：2000年第293卷第3期

页      面：852-860页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：NHLBI NIH HHS [HL59165  HL57952] Funding Source: Medline 

主　　题：血管紧张素Ⅱ/血液 血管紧张素Ⅱ/药理学 心钠素/血液 血压/药物作用 心肌收缩/药物作用 受体 血管紧张素 1型 受体 血管紧张素 2型 受体 血管紧张素/拮抗剂和抑制剂 受体 血管升压素/拮抗剂和抑制剂 钠/血液 猪 血管升压素类/血液 血管升压素类/药理学 心室功能 左/药物作用 动物 男(雄)性 

摘      要：With developing congestive heart failure (CHF), activation of the vasopressin V-1a and angiotensin II type 1 (AT(1)) receptors can occur. In the present study, we examined the direct effects of V-1a receptor blockade (V-1a block), selective AT(1) receptor blockade (AT(1) block), and dual V-1/a/AT(1) receptor blockade (dual block) with respect to left ventricular (LV) function and contractility during the progression of CHF. LV and myocyte functions were examined in pigs with pacing CHF (rapid pacing, 240 beats/min, 3 weeks, n = 10), pacing CHF with concomitant V-1a block (SR49059, 60 mg/kg, n = 8), pacing CHF with concomitant AT(1) block (irbesartan, 30 mg/kg, n = 7), or pacing CHF with dual block (n = 7). LV end-diastolic dimension and peak wall stress were reduced in all receptor blockade groups compared with CHF values. However, LV fractional shortening was increased only in the dual block group compared with CHF values (29 +/- 3 versus 21 +/- 2, P .05). Basal LV myocyte percent shortening increased in the dual block group compared with CHF values (3.44 +/- 0.23 versus 2.88 +/- 0.11, P .05). Although V-1a or AT, block reduced LV loading conditions, only dual block resulted in improved LV and myocyte shortening.