Position reconstruction from an ensemble of hippocampal place cells: Contribution of theta phase coding

作     者：Jensen, O Lisman, JE 

作者机构：Brandeis Univ Dept Biol Volen Ctr Complex Syst Waltham MA 02254 USA 

出 版 物：《JOURNAL OF NEUROPHYSIOLOGY》 (神经生理学杂志)

年 卷 期：2000年第83卷第5期

页      面：2602-2609页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：NIA NIH HHS [AG-12609] Funding Source: Medline NINDS NIH HHS [NS-20331] Funding Source: Medline 

主　　题：Hippocampus Space Perception Theta Rhythm 海马 空间知觉 θ节律 Theta Rhythm Rats FIRING phase coding Systematic errors Hippocampus Space Perception Fire Place Cells 

摘      要：Previous analysis of the firing of individual rat hippocampal place cells has shown that their firing rate increases when they enter a place field and that their phase of firing relative to the ongoing theta oscillation (7-12 Hz) varies systematically as the rat traverses the place held, a phenomenon termed the theta phase precession. To study the relative contribution of phased-coded and rate-coded information, we reconstructed the animal s position on a linear track using spikes recorded simultaneously from 38 hippocampal neurons. Two previous studies of this kind found no evidence that phase information substantially improves reconstruction accuracy. We have found that reconstruction is improved provided epochs with large, systematic errors are first excluded. With this condition, use of both phase and rate information improves the reconstruction accuracy by 43% as compared with the use of rare information alone. Furthermore, it becomes possible to predict the rat s position on a 204-cm track with very high accuracy (error of 3 cm). The best reconstructions were obtained with more than three phase divisions per theta cycle. These results strengthen the hypothesis that information in rat hippocampal place cells is encoded by the phase of theta at which cells fire.