Effects of antibiotic regimens on the fecal shedding patterns of pigs infected with <i>Salmonella</i> typhimurium

作     者：Ebner, PD Mathew, AG 

作者机构：Univ Tennessee Inst Agr Dept Anim Sci Knoxville TN 37996 USA 

出 版 物：《JOURNAL OF FOOD PROTECTION》 (食品保护杂志)

年 卷 期：2000年第63卷第6期

页      面：709-714页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 0836[工学-生物工程] 

主　　题：抗菌药/治疗应用 药物疗法 联合 粪便/微生物学 尼拉霉素/投药和剂量 尼拉霉素/类似物和衍生物 尼拉霉素/治疗应用 土霉素/投药和剂量 土霉素/治疗应用 沙门菌感染 动物/药物疗法 鼠伤寒沙门菌/分离和提纯 猪 猪疾病/药物疗法 猪疾病/微生物学 时间因素 动物 女(雌)性 男(雄)性 

摘      要：An experiment was conducted to determine (i) the effects of antibiotic regimens on the shedding patterns of pigs infected with Salmonella Typhimurium and (ii) whether antibiotic resistance increases the incidence of pathogen shedding. The experiment involved 48 50-day-old pigs challenged with Salmonella Typhimurium and receiving one of four antibiotic regimens including (i) intramuscular injection of ceftiofur sodium followed by inclusion of oxytetracycline in the feed;(ii) apramycin in the feed for 14 days followed by oxytetracycline;(iii) carbadox in the feed until pigs reached 35 kg followed by oxytetracycline;(iv) no antibiotics (control). Fecal samples were collected preinoculation, 2 and 4 days postinoculation (DPI) and at weekly and biweekly intervals thereafter to determine shedding patterns. Salmonella Typhimurium isolates from 2, 4, 7, 21, 42, and 70 DPI were analyzed for antibiotic resistance. A time effect (P 0.05) was observed, indicating that the proportion of isolates resistant to at least one antibiotic varied over time. Overall resistance was determined to be 46% at 2 DPI and increased significantly (P .05) thereafter. Treatment x time and antibiotic x time interactions were also observed (P 0.05) as the percentage of isolates resistant to each test antibiotic increased over time. In no case did the development of antibiotic resistance result in an increased incidence of shedding of the original inoculate. The incidence of shedding was reduced in pigs receiving the apramycin-oxytetracycline treatment, when compared to control pigs;however, no differences were observed between antibiotic treatments.