Emergence of invariant representation of vocalizations in the auditory cortex

作     者：Carruthers, Isaac M. Laplagne, Diego A. Jaegle, Andrew Briguglio, John J. Mwilambwe-Tshilobo, Laetitia Natan, Ryan G. Geffen, Maria N. 

作者机构：Univ Penn Dept Otorhinolaryngol & Head & Neck Surg Philadelphia PA 19104 USA Univ Penn Grad Grp Phys Philadelphia PA 19104 USA Univ Fed Rio Grande do Norte Brain Inst BR-59072970 Natal RN Brazil Univ Penn Grad Grp Neurosci Philadelphia PA 19104 USA 

出 版 物：《JOURNAL OF NEUROPHYSIOLOGY》 (神经生理学杂志)

年 卷 期：2015年第114卷第5期

页      面：2726-2740页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：NIDCD Grants [R03-DC-013660, R01-DC-014479] Klingenstein Foundation Award in Neurosciences Burroughs Wellcome Fund Career Award at Scientific Interface Human Frontiers in Science Foundation Young Investigator Award Pennsylvania Lions Club Hearing Research Fellowship Cognition and Perception IGERT training grant Hearst Foundation Fellowship NSF [PHY1058202] US-Israel BSF 

主　　题：auditory cortex hierarchical coding invariance processing vocalizations 

摘      要：An essential task of the auditory system is to discriminate between different communication signals, such as vocalizations. In everyday acoustic environments, the auditory system needs to be capable of performing the discrimination under different acoustic distortions of vocalizations. To achieve this, the auditory system is thought to build a representation of vocalizations that is invariant to their basic acoustic transformations. The mechanism by which neuronal populations create such an invariant representation within the auditory cortex is only beginning to be understood. We recorded the responses of populations of neurons in the primary and nonprimary auditory cortex of rats to original and acoustically distorted vocalizations. We found that populations of neurons in the nonprimary auditory cortex exhibited greater invariance in encoding vocalizations over acoustic transformations than neuronal populations in the primary auditory cortex. These findings are consistent with the hypothesis that invariant representations are created gradually through hierarchical transformation within the auditory pathway.