In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

作     者：Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu 

作者机构：State Key Laboratory of Luminescence and ApplicationsChangchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences3888 Dong Nanhu RoadChangchun 130033China School of Physical SciencesUniversity of Chinese Academy of SciencesBeijing 100190China Department of Biomedical EngineeringSouthern University of Science and EngineeringShenzhenGuangdong 518055China Research Laboratory for Biomedical Optics and Molecular ImagingInstitute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Jilin Provincial Tumor HospitalChangchunChina Department of Physical ChemistryFaculty of ScienceRegional Centre of Advanced Technologies and MaterialsPalackýUniversity Olomouc78371 OlomoucCzech Republic CAS Key Laboratory of Health InformaticsShenzhen Institutes of Advanced TechnologyShenzhen 518055China. 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2018年第7卷第1期

页      面：182-192页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Project nos.51602304,91739117,81527024,61335001,and 81771930) the Youth Innovation Promotion Association of CAS the Jilin Province Science and Technology Research(Project nos.20170101191JC,20170101042JC,20160520008JH,and 20150519003JH) the Shenzhen Science and Technology Innovation Commission(Grant no.JCYJ20170307110157501) the support by the Operational Proqramme Research,Development and Education-European Reqional Development Fund,Project No.CZ.02.1.01/0.0/0.0/16-019/0000754 of the Ministry of Education,Youth and Sports of the Czech Republic and the assistance provided by the Research Infrastructure NanoEnviCz supported by the Ministry of Education,Youth and Sports of the Czech Republic under Project L01305 of the Ministry of Education,Youth and Sports of the Czech Republic 

主　　题：intravenous injection vivo 

摘      要：Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence *** progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic *** work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic *** real theranostic potential of NIR CDs is enhanced by their unique biodistribution and *** to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration ***,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as *** to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice.