Evaluation of a high-resolution patient-specific model of the electrically stimulated cochlea

作     者：Cakir, Ahmet Dwyer, Robert T. Noble, Jack H. 

作者机构：Vanderbilt Univ Dept Elect Engn & Comp Sci 221 Kirkland Hall Nashville TN 37235 USA Vanderbilt Univ Med Ctr Dept Hearing & Speech Sci Nashville TN USA 

出 版 物：《JOURNAL OF MEDICAL IMAGING》 (J. Med. Imaging)

年 卷 期：2017年第4卷第2期

页      面：025003-025003页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 1009[医学-特种医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：National Institute on Deafness and Other Communication DisordersUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Deafness & Other Communication Disorders (NIDCD) [R01DC014037] NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Deafness & Other Communication Disorders (NIDCD) [R01DC014037] Funding Source: NIH RePORTER 

主　　题：cochlear implant image-based modeling image-guided cochlear implant programming 

摘      要：Cochlear implants (CIs) are surgically implanted medical devices used to treat individuals with severeto-profound sensorineural hearing loss. Although these devices have been remarkably successful at restoring audibility, many patients experience poor outcomes. Our group has developed the first image-guided CI programming technique where the electrode positions are found in CT images and used to estimate neural activation patterns, which is unique information that audiologists can use to define patient-specific processor settings. Currently, neural activation is estimated using only the distance from each electrode to the neural activation sites, which might be less accurate than using high-resolution electro-anatomical models (EAMs) to perform physics-based estimations of neural activation. We propose a patient-customized EAM approach where the EAM is spatially and electrically adapted to a patient-specific configuration. Spatial adaptation is done through nonrigid registration of the model with the patient CT image. Electrical adaptation is done by adjusting tissue resistivity parameters, so the intracochlear voltage distributions predicted by the model best match those directly measured for the patient via their implant. We found that our approach, demonstrated for N = 7 patients, results in mean percent differences between direct and simulated measurements of voltage distributions of 10.9%. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).