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Real-Time, In Vivo Monitoring, and Quantitative Assessment of Intra-Arterial Vasospasm Therapy

实时在监视的 Vivo,并且对 Intra 动脉的血管痉挛治疗的量的评价

作     者:Goelitz, Philipp Kaschka, Iris Lang, Stefan Roessler, Karl Knossalla, Frauke Doerfler, Arnd 

作者机构:Univ Erlangen Nurnberg Dept Neuroradiol Schwabachanlage 6 D-91054 Erlangen Germany Univ Erlangen Nurnberg Dept Neurosurg Erlangen Germany Univ Erlangen Nurnberg Dept Neurol Erlangen Germany 

出 版 物:《NEUROCRITICAL CARE》 (神经重症护理)

年 卷 期:2016年第25卷第1期

页      面:40-46页

核心收录:

学科分类:1002[医学-临床医学] 10[医学] 

主  题:Vascular disease Subarachnoidal hemorrhage Cerebral vasospasm Endovascular treatment Image postprocessing 

摘      要:Our study aimed to evaluate whether the effect of an intra-arterial vasospasm therapy can be assessed quantitatively by in vivo blood flow analysis using the postprocessing algorithm parametric color coding (PCC). We evaluated 17 patients presenting with acute clinical deterioration due to vasospasm following subarachnoidal hemorrhage treated with intra-arterial nimodipine application. Pre- and post-interventional DSA series were post-processed by PCC. The relative time to maximum opacification (rTmax) was calculated in 14 arterially and venously located points of interest. From that data, the pre- and post-interventional cerebral circulation time (CirT) was calculated. Additionally, the arterial vessel diameters were measured. Pre- and post-interventional values were compared and tested for significance, respectively. Flow analysis revealed in all arterial vessel segments a non-statistically significant prolongation of rTmax after treatment. The mean CirT was 5.62 s (+/- 1.19 s) pre-interventionally and 5.16 s (+/- 0.81 s) post-interventionally, and the difference turned out as statistically significant (p = 0.039). A significantly increased diameter was measurable in all arterial segments post-interventionally. PCC is a fast applicable imaging technique that allows via real-time and in vivo blood flow analysis a quantitative assessment of the effect of intra-arterial vasospasm therapy. Our results seem to validate in vivo that an intra-arterial nimodipine application induces not only vasodilatation of the larger vessels, but also improves the microcirculatory flow, leading to a shortened cerebral CirT that reaches normal range post-interventionally. Procedural monitoring via PCC offers the option to compare quantitatively different therapy regimes, which allows optimization of existing approaches and implementation of individualized treatment strategies.

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