Enterotypes in the landscape of gut microbial community composition (vol 3, pg 8, 2017)

作     者：Costea, Paul I. Hildebrand, Falk Arumugam, Manimozhiyan Backhed, Fredrik Blaser, Martin J. Bushman, Frederic D. de Vos, Willem M. Ehrlich, S. Dusko Fraser, Claire M. Hattori, Masahira Huttenhower, Curtis Jeffery, Ian B. Knights, Dan Lewis, James D. Ley, Ruth E. Ochman, Howard O'Toole, Paul W. Quince, Christopher Relman, David A. Shanahan, Fergus Sunagawa, Shinichi Wang, Jun Weinstock, George M. Wu, Gary D. Zeller, Georg Zhao, Liping Raes, Jeroen Knight, Rob Bork, Peer 

作者机构：European Molecular Biology Laboratory Heidelberg Germany. VIB Center for Microbiology VIB Belgium. Laboratory of Microbiology Vrije Universiteit Brussel Brussels Belgium. The Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark. Wallenberg Laboratory Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden. Novo Nordisk Foundation Center for Basic Metabolic Research Section for Metabolic Receptology and Enteroendocrinology Faculty of Health Sciences University of Copenhagen Copenhagen Denmark. New York University Langone Medical Center New York NY USA. Department of Microbiology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA. RPU Immunobiology Department of Bacteriology & Immunology University of Helsinki Helsinki Finland. Laboratory of Microbiology Wageningen University Wageningen The Netherlands. Metagenopolis Institut National de la Recherche Agronomique Jouy en Josas France. King's College London Centre for Host-Microbiome Interactions Dental Institute Central Office Guy's Hospital London UK. Institute for Genome Sciences at the University of Maryland School of Medicine Baltimore MD USA. Graduate School of Advanced Science and Engineering Waseda University Tokyo Japan. Department of Biostatistics Harvard School of Public Health Boston MA USA. APC Microbiome Institute University College Cork Cork Ireland. Biotechnology Institute University of Minnesota Saint Paul MN USA. Department of Computer Science and Engineering University of Minnesota Minneapolis MN USA. Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. MPI Department of Microbiome Science Tübingen Germany. Department of Integrative Biology University of Texas Austin TX USA. Warwick Medical School University of Warwick Coventry UK. Department of Microbiology and Immunology Stanford University Stanford CA USA. Department of Medicine Stanford University Stanford CA USA. Veterans Affairs Palo Alto Health Care System Palo Alto CA USA. Department of Biology Institute of Microbiology ETH Zurich Zurich Switzerland. Department of Biology University of Copenhagen Copenhagen Denmark. Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders King Abdulaziz University Jeddah Saudi Arabia. Macau University of Science and Technology Avenida Wai long Taipa Macau China. Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology University of Hong Kong Pokfulam Hong Kong. The Jackson Laboratory for Genomic Medicine Farmington CT USA. Division of Gastroenterology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Ministry of Education Key Laboratory for Systems Biomedicine Shanghai Centre for Systems Biomedicine Shanghai Jiao Tong University Shanghai China. VIB Center for Microbiology VIB Belgium. jeroen.raes@kuleuven.be. Laboratory of Microbiology Vrije Universiteit Brussel Brussels Belgium. jeroen.raes@kuleuven.be. Department of Microbiology and Immunology Rega Institute KU Leuven Leuven Belgium. jeroen.raes@kuleuven.be. Department of Computer Science University of Colorado Boulder CO USA. robknight@ucsd.edu. Biofrontiers Institute University of Colorado Boulder CO USA. robknight@ucsd.edu. Department of Chemistry and Biochemistry University of Colorado Boulder CO USA. robknight@ucsd.edu. Howard Hughes Medical Institute University of Colorado Boulder CO USA. robknight@ucsd.edu. European Molecular Biology Laboratory Heidelberg Germany. bork@embl.de. Max-Delbrück-Centre for Molecular Medicine Berlin Germany. bork@embl.de. Molecular Medicine Partnership Unit Heidelberg Germany. bork@embl.de. 

出 版 物：《NATURE MICROBIOLOGY》 (Nat. Microbiol.)

年 卷 期：2018年第3卷第3期

页      面：388-388页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

基　　金：MRC [MR/L015080/1, MR/M50161X/1] Funding Source: UKRI Biotechnology and Biological Sciences Research Council [BB/L027801/1] Funding Source: Medline Medical Research Council [MR/L015080/1] Funding Source: Medline Medical Research Council [MR/L015080/1, MR/M50161X/1] Funding Source: Medline NIAID NIH HHS [P30 AI045008] Funding Source: Medline NIDDK NIH HHS [P30 DK050306, UH2 DK083981] Funding Source: Medline NIGMS NIH HHS [R35 GM118038] Funding Source: Medline NIGMS NIH HHS [R01 GM101209] Funding Source: Medline 

主　　题：Community composition landscapes 

摘      要：Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.