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作者机构:Univ Calif Los Angeles Sch Med Laryngeal Dynam Lab Div Head & Neck Surg Los Angeles CA 90095 USA Int Med Ctr Japan Div Otolaryngol Tracheo Esophagol Tokyo Japan
出 版 物:《METHODS OF INFORMATION IN MEDICINE》 (Methods Inf. Med.)
年 卷 期:2005年第44卷第3期
页 面:384-391页
核心收录:
学科分类:1204[管理学-公共管理] 1001[医学-基础医学(可授医学、理学学位)] 0812[工学-计算机科学与技术(可授工学、理学学位)] 10[医学]
主 题:human vocal folds medial surface dynamics empirical eigenfunctions hemi-larynx sustained phonation nonlinear dynamics
摘 要:Objectives: The purpose of this investigation was to use an excised human larynx to substantiate physical mechanisms of sustained vocal fold oscillation over a variety of phonatory conditions. During sustained, flow-induced oscillation, dynamical data was collected from the medial surface of the vocal fold. The method of Empirical Eigenfunctions was used to analyze the data and to probe physical mechanisms of sustained oscillation. Methods. Thirty microsutures were mounted on the medial margin of a human vocal fold. Across five distinct phonatory conditions, the vocal fold was set into oscillation and imaged with a high-speed digital imaging system. The position coordinates of the sutures were extracted from the images and converted into physical coordinates. Empirical Eigenfunctions were computed from the time-varying physical coordinates, and mechanisms of sustained oscillation were explored. Results: Using the method of Empirical Eigenfunctions, physical mechanisms of sustained vocal fold oscillation were substantiated. In particular, the essential dynamics of vocal fold vibration were captured by two dominant Empirical Eigenfunctions. The largest Eigenfunction primarily captured the alternating convergent/divergent shape of the medial surface of the vocal fold, while the second largest Eigenfunction primarily captured the lateral vibrations of the voal fold. Conclusions: The hemi-larynx setup yielded a view of the medial surface of the vocal folds, revealing the tissue vibrations which produced sound. Through the use of Empirical Eigenfunctions, the underlying modes of vibration were computed, disclosing physical mechanisms of sustained vocal fold oscillation. The investigation substantiated previous theoretical analyses and yielded significant data to help evaluate and refine computational models of vocal fold vibration.