Chip-scale gas chromatography:From injection through detection

作     者：Muhammad Akbar Michael Restaino Masoud Agah 

作者机构：VT MEMS LaboratoryBradley Department of Electrical and Computer EngineeringVirginia TechBlacksburgVA 24061USA Department of Biomedical Engineering and MechanicsVirginia TechBlacksburgVA 24061USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2015年第1卷第1期

页      面：8-15页

核心收录：

学科分类：0401[教育学-教育学] 04[教育学] 

基　　金：This work was partially supported by the National Institute for Occupational Safety and Health(NIOSH)under award No.1R21OH010330 and Virginia Tech's Institute for Critical Technology and Applied Science(ICTAS) 

主　　题：gas chromatography lab-on-a-chip MEMS microsystem 

摘      要：Miniaturized gas chromatography(μGC)systems hold potential for the rapid analysis of volatile organic compounds(VOCs)in an extremely compact and low-power enabled ***,we utilize microfabrication technology to demonstrate the single chip integration of the key components of aμGC system in a two-step planar fabrication *** 1.5×3 cm microfluidic platform includes a sample injection unit,a micromachined semi-packed separation column(μSC)and a micro-helium discharge photoionization detector(μDPID).The sample injection unit consists of a T-shaped channel operated with an equally simple setup involving a single three-way fluidic valve,a micropump for sample loading and a carrier gas supply for subsequent analysis of the *** innovative sample injection technique described herein requires a loading time of only a few seconds and produces sharp and repeatable sample pulses(full width at half maximum of approximately 200 ms)at a carrier gas flow rate that is compatible with efficient chromatographic ***,our comprehensive characterization of the chip reveals that a wide variety of VOCs with boiling points in the range of 110–216℃ can be analyzed in less than 1 min by optimizing the flow and temperature programming ***,the analysis of four VOCs at the concentration level of one part per million in an aqueous sample(which corresponds to a headspace concentration in the lower parts-per-billion regime)was performed with a sampling time of only 6 *** μDPID has demonstrated a linear dynamic range over three orders of *** system presented here could potentially be used to monitor hazardous VOCs in real time in industrial workplaces and residential settings.