Epigenetic Mechanisms Underlying the Pathogenesis of Neurogenetic Diseases

作     者：Qureshi, Irfan A. Mehler, Mark F. 

作者机构：Albert Einstein Coll Med Roslyn & Leslie Goldstein Lab Stem Cell Biol & Re Bronx NY 10461 USA Albert Einstein Coll Med Inst Brain Disorders & Neural Regenerat Bronx NY 10461 USA Albert Einstein Coll Med Dept Neurol Bronx NY 10461 USA Albert Einstein Coll Med Dept Neurosci Bronx NY 10461 USA Albert Einstein Coll Med Dept Psychiat & Behav Sci Bronx NY 10461 USA Albert Einstein Coll Med Rose F Kennedy Ctr Res Intellectual & Dev Disabil Bronx NY 10461 USA Albert Einstein Coll Med Einstein Canc Ctr Bronx NY 10461 USA Albert Einstein Coll Med Ruth L & David S Gottesman Stem Cell Inst Bronx NY 10461 USA Albert Einstein Coll Med Ctr Epigen Bronx NY 10461 USA Albert Einstein Coll Med Inst Aging Res Bronx NY 10461 USA 

出 版 物：《NEUROTHERAPEUTICS》 (神经精神疾病治疗)

年 卷 期：2014年第11卷第4期

页      面：708-720页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：National Institutes of Health [NS071571, HD071593, MH66290] F.M. Kirby Foundation Alpern Family Foundation Harold and Isabel Feld Foundation Roslyn and Leslie Goldstein Foundation 

主　　题：Chromatin DNA methylation Epigenetic Epigenome Histone Noncoding RNA 

摘      要：There have been considerable advances in uncovering the complex genetic mechanisms that underlie nervous system disease pathogenesis, particularly with the advent of exome and whole genome sequencing techniques. The emerging field of epigenetics is also providing further insights into these mechanisms. Here, we discuss our understanding of the interplay that exists between genetic and epigenetic mechanisms in these disorders, highlighting the nascent field of epigenetic epidemiology-which focuses on analyzing relationships between the epigenome and environmental exposures, development and aging, other health-related phenotypes, and disease states-and next-generation research tools (i.e., those leveraging synthetic and chemical biology and optogenetics) for examining precisely how epigenetic modifications at specific genomic sites affect disease processes.