Lessons Learned from <i>In Vivo</i> Studies of a Viral Noncoding RNA

作     者：Kincaid, Rodney P. Sullivan, Christopher S. 

作者机构：Univ Texas Austin Inst Cellular & Mol Biol Dept Mol Biosci Ctr Syst & Synthet BiolLaMontagne Ctr Infect Dis Austin TX 78712 USA 

出 版 物：《MSPHERE》 

年 卷 期：2016年第1卷第2期

页      面：e00026-16页

核心收录：

基　　金：Burroughs Wellcome Investigators in Pathogenesis Award Cancer Prevention and Research Institute of Texas [RP110098] Alpha-1 Foundation University of Texas at Austin Institute for Cellular and Molecular Biology 

主　　题：Epstein-Barr virus Kaposi's sarcoma-associated herpesvirus gammaherpesvirus latency microRNA noncoding RNA viral dissemination 

摘      要：Despite increasing interest in the biology of noncoding RNAs (ncRNAs), few functions have been uncovered for viral ncRNAs in vivo. In their recent article in mSphere, Feldman and colleagues [E. R. Feldman et al., mSphere 1(2): e00105-15, 2016, doi: 10.1128/mSphere. 00105-15] demonstrate a highly specific activity of a gammaherpesviral ncRNA in viral dissemination and establishment of latent infection. Their work highlights several interesting features that should be informative to future studies of viral ncRNA.