Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance

作     者：Vasagiri, Nagarjuna Kutala, Vijay Kumar 

作者机构：Nizams Inst Med Sci Dept Clin Pharmacol & Therapeut Hyderabad Andhra Pradesh India Ctr Cellular & Mol Biol Annexure II Hyderabad Andhra Pradesh India 

出 版 物：《MOLECULAR BIOLOGY REPORTS》 (分子生物学报告)

年 卷 期：2014年第41卷第11期

页      面：7705-7714页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：ICMR 

主　　题：BNIP3 Apoptosis Autophagy Epigenetic regulations Mitochondrial permeabilization 

摘      要：BCL-2 [B-cell leukemia/lymphoma 2]/adeno-virus E1B 19KD interacting protein 3 (BNIP3) is an atypical BH3 domain only containing member of Bcl2 family of proteins. BNIP3 is known to be involved in various cellular processes depending on the cell type and conditions and also shown to play a role in various disease conditions including myocardial ischemia, autophagy and apoptosis. Though its role in autophagy and its pro-death activity have been reported in various studies, recent findings have shown its contradictory role in the regulation of these cellular processes. The various studies have shown its epigenetic regulation in disease development and progression and also found to be cytoprotective. In this review, we have focused on the structural and functional aspects of BNIP3 in relation to recent advances of its role in autophagy and apoptosis. Also its role of epigenetic regulation of several genes involved in various diseases was also discussed.