Enzymatic fragments as possible regulatory oligopeptides

作     者：Zamyatnin, A. A. Borchikov, A. S. 

作者机构：Russian Acad Sci Bach Inst Biochem Moscow 119071 Russia Univ Tecn Federico Santa Maria Ctr Biotechnol Valparaiso Chile 

出 版 物：《NEUROCHEMICAL JOURNAL》 (神经化学杂志)

年 卷 期：2007年第1卷第3期

页      面：188-195页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Russian Academy of Sciences  РАН 

主　　题：enzyme bromelain precursor peptide fragment natural oligopeptide neuropeptide neurohormone antimicrobial oligopeptide toxin primary structure the EROP-Moscow data base computer program regulation biogenesis continuum 

摘      要：The enzyme, bromelain, is known to catalyze protein proteolysis and to activate many protective processes occurring with participation of the nervous, immune, and endocrine systems. In this connection, a computer analysis of all the possible 4-6-member fragments of bromelain was performed by means of a comparison of their primary structures with amino acid sequences of all the known natural oligopeptides. Information from the EROP-Moscow data base that contains data on the structures and functions of natural oligopeptides and specially written computer programs were used for this purpose. It was shown that tetra-, penta-, and hexapeptide fragments of the bromelain molecules are involved in amino acid sequences of many natural oligopeptides, including antimicrobial oligopeptides, toxins, neuropeptides, and hormones. These results confirmed deep relationship between the basic regulatory systems. In connection with the obtained data, the process of oligopeptide biogenesis, the possibility of natural formation of regulatory oligopeptides from the bromelain molecules, and correspondence of the obtained results with the conception of oligopeptide continuum are discussed. A possible practical importance of active fragments of protein enzymes in regulatory processes of a living organism is noted.