PanK4 inhibits pancreatic β-cell apoptosis by decreasing the transcriptional level of pro-caspase-9

作     者：Ruo Lan Xiang Yan Li Yang Jin Zuo Xin Hua Xiao Yong Sheng Chang Fu De Fang 

作者机构：National Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesPeking Union Medical College & Chinese Academy of Medical Sciences5# Dong Dan San TiaoBeijing 100005China Peking Union Medical College HospitalBeijing 100730China 

出 版 物：《细胞研究（英文版）》 (CELL RESEARCH)

年 卷 期：2007年第17卷第11期

页      面：966-968页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 100101[医学-人体解剖与组织胚胎学] 071007[理学-遗传学] 10[医学] 

基　　金：TheNationalBasicResearchProgramofChina(2004CB518602,2006CB503909) TheNationalNaturalScienceFoundationofChina(30471930) 

主　　题：半胱氨酸天冬氨酸蛋白酶9/遗传学 细胞凋亡/药物作用 胰岛素分泌细胞/生理学 大鼠 动物 体外研究 

摘      要：Dear Editor:Coenzyme A(CoA)is a primary and predominant acyl group carrier involved in a wide variety of important biochemical *** CoA biosynthetic pathway is composed of five enzymatic steps,of which Pantothenate kinase(PanK)is a key regulatory *** multiple isoforms of PanK are encoded by four difierent genes[1,2].In our previous studies of SNP markers by genotyping the case-controlled DNAs,we found that one SNP within the hPANK4 gene on chromosome 1 was associated with type 2diabetes[3-5].We subsequently showed that rat PanK4 (rPanK4)was up-regulated when rats were challenged by high concentration ofglucose[6].M2-type pyruvate kinase (Pkm2)was found,both in vitro and in vivo,to be associated with rPanK4[7].