Antibacterial and biological properties of silver-loaded coralline hydroxyapatite

作     者：Yu ZHANG Qing-Shui YIN Hua-Fu ZHAO Jian LI Yue-Teng WEI Fu-Zhai CUI Hua-Yang HUANG 

作者机构：Department of Orthopedic Surgery General Hospital of Guangzhou Military Command Guangzhou 510010 China Post-Graduate Institute South China University of Technology Guangzhou 510000 China Department of Orthopedic Surgery General Hospital of Guangzhou Military Command Guangzhou 510010 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China 

出 版 物：《材料学前沿》 (FRONTIERS OF MATERIALS SCIENCE IN CHINA)

年 卷 期：2010年第4卷第4期

页      面：359-365页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the Medical and Health Research Fund of PLA(2006163045) the National Innovation Fund of Medium or Small Science and Technology Enterprise(206404) Guangzhou Science and Technology Key Project(206402) Guangzhou Huadu County Science and Technology Project(HD06G006) 

主　　题：silver-loated loralline hydroxyapatite (Ag-CHA) antibacterial activity cytotoxicity 

摘      要：The antibacterial and biological properties of silver-loated coralline hydroxyapatite (Ag-CHA) as a new antibacterial implant material were investigated in this study. Compared to other antibiotic and chemical bactericidal agents, Ag+ does not bring bacterial resistance to drugs and has less toxicity. The porous CHA was formed by hydrothermal exchange, then Ag+ was loated onto CHA through ion exchange and adsorption. The microstructure and composition of Ag-CHA were characterized by scanning electron microscopy (SEM), Rutherford backscattering spectrometry (RBS), and energy dispersive spectrometry (EDS). Antibacterial activity of Ag-CHA on the clinical strains of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by the flat plate diffusion method. The antibacterial activity of Ag-CHA was found to be correlated with the concentration of Ag+ in a dose-dependent manner, which indicated that the optimal antibacterial and biocompatible effects of Ag-CHA could be obtained with Ag+ concentrations from 5×10-5to 1×10-4mol/L.