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Reduction of pulmonary mast cells in areas of acute inflammation in calves with <i>Mannheimia</i> (<i>Pasteurella</i>) <i>haemolytica</i> pneumonia

在在有 Mannheimia (巴斯德氏菌属) 的小牛的急性炎的区域的肺的肥大细胞的减小溶血肺病

作     者:Ramírez-Romero, R Brogden, KA Gallup, JM Dixon, RAF Ackermann, MR 

作者机构:Iowa State Univ Coll Vet Med Dept Vet Pathol Ames IA 50011 USA USDA ARS Natl Anim Dis Ctr Ames IA 50010 USA Texas Biotechnol Corp Houston TX 77030 USA 

出 版 物:《JOURNAL OF COMPARATIVE PATHOLOGY》 (比较病理学杂志)

年 卷 期:2000年第123卷第1期

页      面:29-35页

核心收录:

学科分类:1001[医学-基础医学(可授医学、理学学位)] 0906[农学-兽医学] 09[农学] 

基  金:USDA/NRI, (970– 2654) Consejo Nacional de Ciencia y Tecnología, CONACYT Universidad Autónoma de Nuevo León, UANL 

主  题:急性病 联苯化合物/治疗应用 细胞计数/兽医学 荧光抗体技术 直接/兽医学 肺/免疫学 肺/病理学 溶血性曼氏杆菌 甘露糖苷类/治疗应用 肥大细胞/免疫学 肥大细胞/病理学 巴斯德菌病 肺/药物疗法 巴斯德菌病 肺/免疫学 巴斯德菌病 肺/病理学 动物  男(雄)性 

摘      要:Mast cells in the left cranial pulmonary lobe of colostrum-deprived neonatal calves were quantified 2 and 6 h after intrabronchial inoculation with Mannheimia (Pasteurella) haemolytica Al. The mast cells were detected ii) immunohistochemically with a mouse anti-human mast cell tryptase monoclonal antibody, and (2) by metachromatic staining with low pH toluidine blue. A greater number of mast cells was demonstrated by the second method than by the first. At 6 h after inoculation, but not at 2 h, the number of mast cells was significantly reduced at the site of the main lesions. Treatment of calves with a sialyl Lewis mimetic (TBC 1269) did not appreciably affect the results at 6 h. (C) 2000 Harcourt Publishers Ltd.

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