Regulation of the mammalian epigenome by long noncoding RNAs

作     者：Whitehead, Joanne Pandey, Gaurav Kumar Kanduri, Chandrasekhar 

作者机构：Uppsala Univ Rudbeck Lab Dept Genet & Pathol S-75185 Uppsala Sweden CNRS Inst Curie UMR168 F-75005 Paris France 

出 版 物：《BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS》 (Biochim. Biophys. Acta Gen. Subj.)

年 卷 期：2009年第1790卷第9期

页      面：936-947页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：Swedish Research Council Swedish Medical Research Council Swedish Cancer Research Foundation VR-M 

主　　题：Noncoding RNA Chromatin Epigenetic Antisense RNA Gene regulation 

摘      要：Genomic analyses have demonstrated that although less than 2% of the mammalian genome encodes proteins, at least two thirds is transcribed. Many nontranslated RNAs have now been characterized, and several long transcripts, ranging from 0.5 to over 100 kb, have been shown to regulate gene expression by modifying chromatin structure. Functions uncovered at a few well characterized loci demonstrate a wide diversity of mechanisms by which long noncoding RNAs can regulate chromatin over a single promoter, a gene cluster, or an entire chromosome, in order to activate or silence genes in cis or in trans. In reviewing the activities of these ncRNAs, we will look for common features in their interactions with the chromatin modifying machinery, and highlight new experimental approaches by which to address outstanding issues in ncRNA-dependent regulation of gene expression in development, disease and evolution. (C) 2008 Elsevier B.V. All rights reserved.