Accuracy of CT-guided transthoracic needle biopsy of lung lesions: factors affecting diagnostic yield

作     者：Priola, A. M. Priola, S. M. Cataldi, A. Errico, L. Di Franco, M. Campisi, P. Molinaro, L. Marci, V. Novello, S. Fava, C. 

作者机构：Univ Turin ASO San Luigi Gonzaga I-10043 Orbassano TO Italy Univ Turin ASO San Giovanni Battista Turin Italy 

出 版 物：《RADIOLOGIA MEDICA》 (放射医学)

年 卷 期：2007年第112卷第8期

页      面：1142-1159页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 1009[医学-特种医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：lung biopsy computed tomography (CT) guidance accuracy 

摘      要：Purpose. This study was performed to analyse the variables affecting the diagnostic accuracy of computed tomography (CT)-guided transthoracic needle biopsy of pulmonary lesions. Materials and methods. A retrospective study of 612 consecutive procedures with confirmed final diagnoses was undertaken. Benign and malignant needle biopsy results were compared with final outcomes to determine diagnostic accuracy. A statistical analysis of factors related to patient characteristics, lung lesions and biopsy technique was performed to determine possible influences on diagnostic yield. A p value less than 0.05 was interpreted as statistically significant. Results. There were 508 (83%) malignant and 104 (17%) benign lesions. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for a diagnosis of malignancy were 90.2%. 99.0%. 99.8%. 67.3% and 91.7%, respectively. Overall diagnostic accuracy was 83.3%. Variables affecting diagnostic accuracy were the final diagnosis (benign 67%, malignant 92%;p5 cm 78%;p0.05). Conclusions. In CT-guided transthoracic needle biopsy, the final diagnosis and lesion size affect diagnostic accuracy: benign lung lesions and lesions smaller than 1.5 cm or larger than 5.0 cm in diameter provide lower diagnostic yield.