Capillary damage in skeletal muscle in advanced Chagas' disease patients

作     者：Torres, SH Finol, HJ de Oca, MM Vaásquez, F Puigbó, JJ Loyo, JG 

作者机构：Cent Univ Venezuela Inst Expt Med Fac Med Caracas 1050 A Venezuela Cent Univ Venezuela Ctr Electron Microscopy Fac Sci Caracas 1050 A Venezuela Cent Univ Venezuela Div Pulm Univ Hosp Caracas Caracas 1050 A Venezuela Cent Univ Venezuela Cardiomyopathy Unit Univ Hosp Caracas Caracas 1050 A Venezuela 

出 版 物：《PARASITOLOGY RESEARCH》 (寄生虫学研究)

年 卷 期：2004年第93卷第5期

页      面：364-368页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 

基　　金：Consejo de Desarrollo Científico y Humanístico, Universidad Central de Venezuela, CDCH-UCV Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, CIEMAT, (S1-97001106) Universidad Central de Venezuela, UCV, (09.33.4367.1999) 

主　　题：Capillaries Chagas Disease Muscle Skeletal 

摘      要：The damage to skeletal muscle capillaries in advanced Chagas disease (stages II and III) was investigated in the vastus lateralis muscle of six patients and compared to that of six normal subjects. Capillaries were visualized by the PAS-amylase reaction and muscle fibres were classified by the ATPase histochemical method. Transmission electron microscopy was used to look for capillary alterations. The capillary-to-fibre ratio and number of capillaries adjacent to type I and type IIa fibres were decreased in the patient group. At the ultrastructural level, all patients showed capillary abnormalities, mainly basement membrane thickening and reduplication, capillary occlusion, proliferative endothelial cell cytoplasm with dense bodies, large vacuoles, altered mitochondria and prominent rough endoplasmic reticulum, as well as pericyte abnormalities. Capillary alterations are similar to those in patients affected by autoimmune diseases, suggesting an autoimmune component in the chronic phase of this disease. The reduction in capillarity may contribute to altered muscle performance in these patients.