Self-Tracking Energy Transfer for Neural Stimulation in Untethered Mice

作     者：John S. Ho Yuji Tanabe Shrivats Mohan Iyer Amelia J. Christensen Logan Grosenick Karl Deisseroth Scott L. Delp Ada S. Y. Poon 

作者机构：Department of Electrical Engineering Stanford University Stanford California 94305 USA Department of Bioengineering Stanford University Stanford California 94305 USA Neurosciences Program Stanford University Stanford California 94305 USA Department of Psychiatry and Behavioral Sciences Stanford University Stanford California 94305 USA Howard Hughes Medical Institute Stanford University Stanford California 94305 USA CNC Program Stanford University Stanford California 94305 USA Department of Mechanical Engineering Stanford University Stanford California 94305 USA 

出 版 物：《Physical Review Applied》 (Phys. Rev. Appl.)

年 卷 期：2015年第4卷第2期

页      面：024001-024001页

核心收录：

学科分类：07[理学] 0702[理学-物理学] 

基　　金：U.S. Department of Defense 

主　　题：Brain Neuronal network activity Neuronal imaging 

摘      要：Optical or electrical stimulation of neural circuits in mice during natural behavior is an important paradigm for studying brain function. Conventional systems for optogenetics and electrical microstimulation require tethers or large head-mounted devices that disrupt animal behavior. We report a method for wireless powering of small-scale implanted devices based on the strong localization of energy that occurs during resonant interaction between a radio-frequency cavity and intrinsic modes in mice. The system features self-tracking over a wide (16-cm diameter) operational area, and is used to demonstrate wireless activation of cortical neurons with miniaturized stimulators (10 mm3, 20 mg) fully implanted under the skin.