Time-dependent information transmission in a model regulatory circuit

作     者：F. Mancini C. H. Wiggins M. Marsili A. M. Walczak 

作者机构：International School for Advanced Studies (SISSA) Trieste Italy Department of Applied Physics and Applied Mathematics Center for Computational Biology and Bioinformatics Columbia University New York New York 10027 USA The Abdus Salam International Centre for Theoretical Physics (ICTP) Trieste Italy CNRS and Laboratoire de Physique Théorique de l’École Normale Supérieure Paris France 

出 版 物：《Physical Review E》 (物理学评论E辑：统计、非线性和软体物理学)

年 卷 期：2013年第88卷第2期

页      面：022708-022708页

核心收录：

学科分类：07[理学] 070203[理学-原子与分子物理] 0702[理学-物理学] 

基　　金：Marie Curie Career Integration Grant 

主　　题：GENE regulatory networks STRESS (Physiology) SIGNAL processing TOPOLOGY INFORMATION networks DYNAMICAL systems 

摘      要：Many biological regulatory systems respond with a physiological delay when processing signals. A simple model of regulation which respects these features shows how the ability of a delayed output to transmit information is limited: at short times by the time scale of the dynamic input, at long times by that of the dynamic output. We find that topologies of maximally informative networks correspond to commonly occurring biological circuits linked to stress response and that circuits functioning out of steady state may exploit absorbing states to transmit information optimally.