Renal tubulointerstitial fibrosis - New thoughts on its development and progression

作     者：O'Donnell, MP 

作者机构：Minneapolis Med Res Fdn Inc Minneapolis MN 55404 USA Hennepin Cty Med Ctr Dept Med Div Nephrol Minneapolis MN 55415 USA 

出 版 物：《POSTGRADUATE MEDICINE》 

年 卷 期：2000年第108卷第1期

页      面：159-+页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：血管紧张素Ⅱ/代谢 上皮/生理学 纤维化 肾功能衰竭 慢性/药物疗法 肾功能衰竭 慢性/病理学 肾功能衰竭 慢性/病理生理学 肾小管/代谢 肾小管/病理学 肾小管/病理生理学 转化生长因子β/生理学 人类 

摘      要：Tubulointerstitial fibrosis, characterized by accumulation of extracellular matrix proteins, is a morphologic hallmark of chronic renal disease as well as a component of normal aging in the kidney and of chronic allograft nephropathy. In this article, the author describes patterns that have recently been proposed to explain the pathogenesis of tubulointerstitial injury. In addition, he discusses available and experimental pharmacologic interventions that may ameliorate renal fibrosis.