Antenatal glucocorticoids alter postnatal preterm lamb renal and cardiovascular responses to intravascular volume expansion

作     者：Smith, LM Ervin, MG Wada, N Ikegami, M Polk, DH Jobe, AH 

作者机构：Univ Calif Los Angeles Harbor UCLA Med Ctr Sch Med Martin Res CtrDept PediatPerinatal Res Labs Torrance CA 90502 USA Univ Calif Los Angeles Harbor UCLA Med Ctr Sch Med Dept Obstet & Gynecol Torrance CA 90502 USA 

出 版 物：《PEDIATRIC RESEARCH》 (儿科研究)

年 卷 期：2000年第47卷第5期

页      面：622-627页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：NCRR NIH HHS [3 M01 RR00425-2754] Funding Source: Medline NICHD NIH HHS [HD-29713] Funding Source: Medline 

主　　题：醛固酮/血液 血管紧张素Ⅱ/血液 倍他米松/投药和剂量 血量/生理学 心血管系统/胚胎学 乙醇胺类/血液 胎血/化学 肾小球滤过率/药物作用 糖皮质激素类/投药和剂量 血流动力学/药物作用 输注 静脉内 注射 肌肉内 肾/药物作用 肾/胚胎学 肾/生理学 分娩 过早/药物疗法 产前暴露迟发效应 肾循环/药物作用 肾素/血液 绵羊 氯化钠/投药和剂量 尿动力学/药物作用 水电解质平衡/药物作用 动物 女(雌)性 妊娠 

摘      要：We assessed renal and cardiovascular function in preterm newborn lambs after antenatal glucocorticoid exposure. Pregnant ewes were randomly assigned to receive betamethasone or saline via either direct fetal or maternal injection at 122 d gestation. Lambs were delivered 15 h later, and cardiovascular and renal function was assessed. Two hours after delivery, baseline urine flow, urinary sodium excretion, and urinary osmolar clearance were similar in all groups. Volume expansion (saline, 2.58 of body weight, for 10 min) increased values for urine flow (0.23 +/- 0.04 to 0.58 +/- 0.09 ***(-1).kg(-1)), urinary sodium excretion (29.7 +/- 5.8 to 76.2 +/- 12.3 mu ***(-1).kg(-1)), and osmolar clearance (12.2. +/- 1.2 to 24.3 +/- 1.6 mL/100 mL GFR) in the fetal group. Increases in urine values were also observed in the maternal group, but control values did not change significantly. Mean arterial pressure was increased in both betamethasone-treated groups relative to controls. Short-term antenatal betamethasone exposure I) augments preterm newborn kidney adaptive responses to acute volume expansion, and 2) increases postnatal blood pressure in preterm newborn lambs.