Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

作     者：Almehizia, Abdulrahman A. Abuelizz, Hatem A. Taie, Hanan A. A. ElHassane, Anouar Marzouk, Mohamed Al-Salahi, Rashad 

作者机构：King Saud Univ Coll Pharm Dept Pharmaceut Chem POB 2457 Riyadh 11451 Saudi Arabia Natl Res Ctr Div Agr & Biol Res Plant Biochem Dept 33 El Bohouth StEl Tahrir St Giza 12622 Egypt Prince Sattam bin Abdulaziz Univ Coll Sci & Humanities Dept Chem POB 83 Alkharj 11942 Saudi Arabia Natl Res Ctr Ctr Excellence Adv Sci Chem Nat Prod Grp 33 El Bohouth StEl Tahrir St Giza 12622 Egypt 

出 版 物：《SAUDI PHARMACEUTICAL JOURNAL》 (沙特药学杂志)

年 卷 期：2019年第27卷第1期

页      面：133-137页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Deanship of Scientific Research at King Saud University [RG-1439-011] 

主　　题：Benzotriazoloquinazolines DPPH BHT DFT Antioxidant capacity 

摘      要：Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1-16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1-16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent. Density functional theory was carried out to explain the relative importance of C=O, C=S and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.