Eukaryotic noncoding DNA sequences provide genes with an additional protection against chemical mutagens

作     者：Patrushev, L. I. Minkevich, I. G. 

作者机构：Russian Acad Sci Shemyakin Ovchinnikov Inst Bioorg Chem Moscow 117997 Russia Russian Acad Sci Skryabin Inst Biochem & Physiol Microorg Pushchino 142290 Moscow Oblast Russia 

出 版 物：《RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY》 (俄罗斯生物有机化学杂志)

年 卷 期：2006年第32卷第4期

页      面：368-372页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 0703[理学-化学] 

主　　题：coding sequences evolution genome noncoding sequences mutations C-value paradox 

摘      要：A quantitative model was developed that identified a new function of noncoding sequences in the eukaryotic genome, namely, the protection of coding sequences against chemical (mainly endogenous) mutagens. It was shown that, under common ecological conditions, the number of nucleotides damaged by endogenous and exogenous reactive species in coding sequences of the genome is inversely proportional to the size of their noncoding parts. Noncoding sequences can differently protect single genetic loci from chemical modification by the formation of specific spatial structures of the protected loci in the interphase nuclei. The significant differences in genome sizes between species (C-value paradox) can be explained by different contributions of noncoding sequences to the total effect of genome protection from endogenous chemical mutagens.