4D Flow MRI quantification of blood flow patterns, turbulence and pressure drop in normal and stenotic prosthetic heart valves

作     者：Ha, Hojin Kvitting, John-Peder Escobar Dyverfeldt, Petter Ebbers, Tino 

作者机构：Kangwon Natl Univ Dept Mech & Biomed Engn Chunchon South Korea Linkoping Univ Div Cardiovasc Med Dept Med & Hlth Sci Linkoping Sweden Linkoping Univ Ctr Med Image Sci & Visualizat CMIV Linkoping Sweden Oslo Univ Hosp Rikshosp Dept Cardiothorac Surg Oslo Norway 

出 版 物：《MAGNETIC RESONANCE IMAGING》 (磁共振成像)

年 卷 期：2019年第55卷

页      面：118-127页

核心收录：

学科分类：080805[工学-电工理论与新技术] 080904[工学-电磁场与微波技术] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 1009[医学-特种医学] 

基　　金：European Union Seventh Framework Programme, European-Union (FP7/2007-2013) Swedish Research Council, Sweden [2013-6077, 2014-6191] Basic Science Research Program through the National Research Foundation of Korea, South Korea (NRF) - Ministry of Education [2018R1D1A1A02043249] 

主　　题：Turbulence Reynolds stress Pressure drop Magnetic resonance imaging Phase contrast MRI 4D PC-MRI 4D Flow MRI 

摘      要：Purpose: To assess valvular flow characteristics and pressure drop in a variety of normal and stenotic prosthetic heart valves (PHVs) using 4D Flow MRI. Materials and methods: In-vitro flow phantoms with four different PHVs were studied: Medtronic-Hall tilting disc, St. Jude Medical standard bileaflet (STJM), Medtronic CoreValve Evolut R and Edwards SAPIEN 3. The valvular flow characteristics were investigated in normal and stenotic PHVs by using 4D Flow MRI. Results: The results showed that each valve provided a different amount of signal loss in the 4D Flow MRI. The defect size of the signal loss from each valve was 37.5 mm, 39.0 mm, 37.5 mm and 51.0 mm for the Tilting disk, STJM, SAPIEN 3 and CoreValve, respectively. The 4D Flow MRI-based estimation of the elevation of the pressure drop through the stenotic PHV using both Bernoulli-based and turbulence-based methods correlated well with the true values for the Tilting disc, STJM and SAPIEN 3 valve. However, the obstructive hemodynamics in the stenotic CoreValve was not clearly identified due to the large signal void from the long struts, resulting in a severe underestimation of the pressure drop using 4D Flow MRI. Conclusion: The Tilting disc, STJM and SAPIEN 3 valves provided reasonable estimates of peak velocity, turbulence production and the corresponding pressure drop. In contrast, the large strut of the CoreValve and corresponding signal void prevented accurate measurements of the velocity and turbulence production;therefore, 4D Flow MRI prediction of the pressure drop through the CoreValve was not feasible.