Noncoding RNA for personalized prostate cancer treatment: utilizing the 'dark matters' of the genome

作     者：Hua, Junjie Lu, Jennifer Isaev, Keren Soares, Fraser Guo, Haiyang Ahmed, Musaddeque He, Housheng Hansen 

作者机构：Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada Univ Toronto Dept Med Biophys Toronto ON Canada Univ Toronto Dept Lab Med & Pathobiol Toronto ON Canada 

出 版 物：《PERSONALIZED MEDICINE》 (个性化医疗)

年 卷 期：2017年第14卷第2期

页      面：159-169页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Princess Margaret Cancer Foundation Canada Foundation for Innovation Ontario Research Fund [CFI32372] NSERC WICC Ontario 20th Anniversary Prostate Cancer Innovation Grant of the CCS CIHR Transitional Operating Grant Movember Rising Star Award Prostate Cancer Canada OMIR Terry Fox New Investigator Award CIHR 

主　　题：biomarker noncoding RNA personalized medicine prostate cancer therapy 

摘      要：Prostate cancer is the most commonly diagnosed cancer in men in western countries, with significant health impact. Clinically, it is complicated with the lack of biomarkers and effective treatments for aggressive disease, particularly castration-resistant prostate cancer. Although we have gained much insight into the biology of prostate cancer through studying protein-coding genes, they represent only a small fraction of our genome. Therefore, it is essential for us to investigate noncoding RNAs, which comprise the majority of our transcriptome, in order to achieve a better understanding of prostate cancer and move toward personalized medicine. In this article, we will address recent advancements in our knowledge of noncoding RNAs, and discuss the clinical potentials and challenges of different types of noncoding RNAs in prostate cancer.