Pharmacogenetics of tomorrow: the 1+1=3 principle

作     者：Pander, Jan Wessels, Judith A. M. Mathijssen, Ron H. J. Gelderblom, Hans Guchelaar, Henk Jan 

作者机构：Leiden Univ Ctr Med Dept Clin Pharm & Toxicol NL-2300 RC Leiden Netherlands Dr Daniel Den Hoed Canc Ctr Erasmus Med Ctr Dept Med Oncol NL-3008 AE Rotterdam Netherlands Leiden Univ Ctr Med Dept Clin Oncol NL-2300 RC Leiden Netherlands 

出 版 物：《PHARMACOGENOMICS》 (药物基因组学)

年 卷 期：2010年第11卷第7期

页      面：1011-1017页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：classification and regression tree multifactor dimensionality reduction pharmacogenetics sunitinib toxicity 

摘      要：Disappointing results from replicating pharmacogenetic association studies have prompted the search for novel statistical techniques to analyze the data, while taking into account the biological complexity underlying drug response. Two of these techniques multifactor dimensionality reduction and classification and regression tree analysis will probably be applied in increasing numbers of future pharmacogenetic studies. In this article, we describe the concepts underlying both techniques and illustrate their application in a recent pharmacogenetic study.