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作者机构:Department of Biomedical Engineering Boston University 44 Cummington Street Boston Massachusetts 02215 USA Physiology Program Department of Environmental Health Harvard School of Public Health Boston Massachusetts 02115 USA Department of Physics Boston University Boston Massachusetts 02215 USA
出 版 物:《Physical Review Letters》 (Phys Rev Lett)
年 卷 期:2006年第97卷第16期
页 面:168101-168101页
核心收录:
基 金:National Heart Lung and Blood Institute NHLBI (P01HL033009)
主 题:Polymers
摘 要:We report on a model of a prestressed nonlinear semiflexible polymer chain that links thermally driven dynamics to the creep behavior of living cells. Numerical simulations show that the chain’s creep follows a power law with an exponent that decreases with increasing prestress. This is related to the propagation of free energy through the chain in response to stretching, where the propagation speed is regulated by the prestress via the chain’s nonlinear elasticity. These results indicate that the main aspects of cell rheology are consistent with the dynamics of single polymer chains under tension.