Sampling tissue volumes using frequency-domain photon migration

作     者：Frédéric Bevilacqua Joon S. You Carole K. Hayakawa Vasan Venugopalan 

作者机构：Laser Microbeam and Medical Program Beckman Laser Institute 1002 Health Sciences Road East Irvine California 92612 USA Department of Biomedical Engineering Univeristy of California–Irvine Irvine Calfornia 92697 USA Department of Chemical Engineering and Materials Science University of California–Irvine Irvine California 92697 USA 

出 版 物：《Physical Review E》 (物理学评论E辑：统计、非线性和软体物理学)

年 卷 期：2004年第69卷第5期

页      面：051908-051908页

核心收录：

学科分类：07[理学] 070203[理学-原子与分子物理] 0702[理学-物理学] 

基　　金：National Institute of Biomedical Imaging and Bioengineering, NIBIB, (R01EB000345) National Institute of Biomedical Imaging and Bioengineering, NIBIB 

主　　题：Tissue 

摘      要：We demonstrate the use of Monte Carlo simulations to generate photon scattering density functions (PSDFs) that represent the tissue volume sampled by steady-state and frequency-domain photon migration. We use these results to illustrate how scaling laws can be developed to determine the mean sampling depth of the multiply scattered photons detected by photon migration methods that remain valid outside the bounds of the standard diffusion approximation, i.e., at small source-detector separations and in media where the optical absorption is significant relative to scattering. Using both the PSDF computation and the newly formulated scaling laws, we focus on a comprehensive description of the effects of source modulation frequency, optical absorption, and source-detector separation on the depth of the sampled tissue volume as well as the sensitivity of frequency-domain photon migration measurements to the presence of a localized absorption heterogeneity.