Highly Sensitive FPW-Based Microsystem for Rapid Detection of Tetrahydrocannabinol in Human Urine

作     者：Lan, Je-Wei Hsieh, Chia-Hsu Huang, I-Yu Lin, Yu-Cheng Tsai, Tsung-Yi Wang, Chua-Chin 

作者机构：Natl Sun Yat Sen Univ Dept Elect Engn Kaohsiung 80424 Taiwan Natl Cheng Kung Univ Dept Engn Sci Tainan 70101 Taiwan 

出 版 物：《SENSORS》 (传感器)

年 卷 期：2017年第17卷第12期

页      面：2760-2760页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 0808[工学-电气工程] 07[理学] 0804[工学-仪器科学与技术] 0703[理学-化学] 

基　　金：Ministry of Science and Technology [MOST 105-2622-E-006-018-CC2  MOST 105-2218-E-110-006  MOST 105-2221-E-110-080  MOST 104-2622-E-006-040-CC2] 

主　　题：flexural plate-wave tetrahydrocannabinol circular-type interdigital transducer reflective grating structure low insertion loss field-programmable gate array readout system 

摘      要：This paper presents a highly sensitive flexural plate-wave (FPW)-based microsystem for rapid detection of tetrahydrocannabinol (THC) in human urine. First, a circular-type interdigital transducer (IDT) was integrated with a circular-type silicon-grooved reflective grating structure (RGS) to reduce insertion loss. Then, with lower insertion loss (-38.758 dB), the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL) and high mass-sensitivity (126.67 cm(2)/g). Finally, this biosensor was integrated with field-programmable gate array (FPGA) board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992.