Long non-coding RNA: Functional agent for disease traits

作     者：Jain, Sriyans Thakkar, Nirav Chhatai, Jagamohan Bhadra, Manika Pal Bhadra, Utpal 

作者机构：CSIR Ctr Cellular & Mol Biol Funct Genom & Gene Silencing Grp Hyderabad Andhra Pradesh India Indian Inst Chem Technol Ctr Chem Biol Hyderabad Andhra Pradesh India 

出 版 物：《RNA BIOLOGY》 (核糖核酸生物学)

年 卷 期：2017年第14卷第5期

页      面：522-535页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：CSIR network project of India [B.S. C.0121] DBT Drosophila project [GAP0362] 

主　　题：Biomarkers epigenetics gene regulation human diseases long non-coding RNA therapeutic agents 

摘      要：In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers with their involvement in all facets of life. LncRNAs are transcripts of more than 200 nucleotides which lack defined protein coding potential. Although they do not code for proteins, a large number of them are involved in regulating gene expression and translation. The presence of numerous lncRNAs in the human genome has prompted us to investigate the contribution of these molecules to human biology and medicine. In this review, we present the potential role of lncRNAs interlinked to different human diseases and genetic disorders. We also describe their role in cellular differentiation and aging and discuss their potential importance as biomarkers and as therapeutic agents.