Two new monoterpene lactones from Ligularia rumicifolia (JRDrumm.) SWLiu and their anti-proliferative activities

作     者：Zhang, Jing Jiang, Wei Cao, Hong-Jie Qu, Yanbo Liao, Zhi-Xin Liu, Chao Sun, Jin-Yue 

作者机构：Southeast Univ Jiangsu Prov Hitech Key Lab Biomed Res Sch Chem & Chem Engn Dept Pharmaceut Engn Nanjing 211189 Jiangsu Peoples R China Shandong Acad Agr Sci Inst Agrofood Sci & Technol Key Lab Agroprod Proc Technol Shandong Prov Key Lab Novel Food Resources ProcMinist Agr Jinan 250100 Shandong Peoples R China 

出 版 物：《PHYTOCHEMISTRY LETTERS》 (植物化学快报)

年 卷 期：2018年第28卷

页      面：55-58页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 071001[理学-植物学] 07[理学] 

基　　金：National Natural Science Foundation of China National Science and Technology Support Program of China [2015BAD16B02] Priority Academic Program Development of Jiangsu Higher Education Institutions Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2016-B06] 

主　　题：Ligularia rumicifolia (JRDrumm.) SWLiu Monoterpene lactones Anti-proliferative 

摘      要：A phytochemical study of the EtOAc extract of Ligularia rumicifolia (***.) *** led to the isolation of two new monoterpene lactones (1-2) named (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid and (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid methyl ester, along with nine known compounds (3-11). All compounds were isolated from this species for the first time. Their structures were established on the basis of spectroscopic methods. The cytotoxic activity of Compound 2 was weak, with the lowest IC50 value of 80.84 mu M against MCF-7 cells. Compound 1 exhibited better anti-proliferative activities against MCF-7, T-24, HepG-2 and SKOV-3 cell lines than Compound 2, with the lowest IC50 value of 66.12 mu M against MCF-7 cells.