Simplified laser-speckle-imaging analysis method and its application to retinal blood flow imaging

作     者：Cheng, Haiying Duong, Timothy Q. 

作者机构：Emory Univ Yerkes Imaging Ctr Dept Neurol Atlanta GA 30329 USA 

出 版 物：《OPTICS LETTERS》 (光学快报)

年 卷 期：2007年第32卷第15期

页      面：2188-2190页

核心收录：

学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：NEI NIH HHS [R01 EY014211-07  R01 EY014211-06  R01 EY014211  R01 EY018855-01A1  NEI R01-EY014211  R01 EY018855-02  R01 EY018855  R01 EY018855-03  R01 EY014211-09  R01 EY014211-01A1  R01 EY014211-05  R01 EY014211-02  R01 EY014211-04  R01 EY014211-03  R01 EY014211-08] Funding Source: Medline 

主　　题：Analytical techniques Computation methods Laser Doppler velocimetry Laser imaging Phantom studies Speckle patterns 

摘      要：Laser speckle imaging (LSI) is widely used to study blood flow at high spatiotemporal resolution. Several papers recently pointed out that the commonly used LSI equation involves an approximation that could result in incorrect data analysis. We investigated the impact of such an approximation and introduced a simplified analysis method to improve computation time. Flow phantom studies were performed for validation. Moreover, we demonstrated a novel LSI application by imaging blood flow of rat retinas under normal and physiologic-challenge conditions. Because blood-flow abnormality is implicated in many retinal diseases, LSI could provide valuable physiologic, and potentially diagnostic, information. (C) 2007 Optical Society of America.