Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation

作     者：Vasan Venugopalan Arnold Guerra, III Kester Nahen Alfred Vogel 

作者机构：Department of Chemical Engineering and Materials Science University of California Irvine California 92697-2575 Laser Microbeam and Medical Program Beckman Laser Institute University of California Irvine California 92612-3010 Center for Biomedical Engineering University of California Irvine California 92697-2715 Medical Laser Center Lübeck Peter Monnik Weg 4 D-23562 Lübeck Germany 

出 版 物：《Physical Review Letters》 (Phys Rev Lett)

年 卷 期：2002年第88卷第7期

页      面：078103-078103页

核心收录：

学科分类：07[理学] 0702[理学-物理学] 

基　　金：NCRR NIH HHS [P41-RR-01192  R01-RR-14892] Funding Source: Medline 

主　　题：Cells 

摘      要：We investigate experimentally the physical processes underlying pulsed cellular microsurgery and micromanipulation using nanosecond 532- and 1064-nm laser pulses focused at high numerical aperture. We find that the laser parameters employed for many microirradiation techniques are congruent with those leading to optical breakdown in water. We determine the size and shape of the laser-induced plasma, pressure of the emitted shock wave, and size and energy of the cavitation bubble formed by the expanding plasma. We discuss implications of the results for biophysical microirradiation procedures.