The importance of miRNAs and epigenetics in acute lymphoblastic leukemia prognosis

作     者：Ranjbar, Reza Karimian, Ansar Fard, Arad Aghaie Tourani, Mehdi Majidinia, Maryam Jadidi-Niaragh, Farhad Yousefi, Bahman 

作者机构：Baqiyatallah Univ Med Sci Mol Biol Res Ctr Tehran Iran Babol Univ Med Sci Hlth Res Inst Cellular & Mol Biol Res Ctr Babol Sar Iran Kurdistan Univ Med Sci Canc & Immunol Res Ctr Sanandaj Iran Babol Univ Med Sci Student Res Comm Babol Sar Iran Tarbiat Modares Univ Fac Med Sci Dept Hematol Tehran Iran Urmia Univ Med Sci Solid Tumor Res Ctr Orumiyeh Iran Tabriz Univ Med Sci Immunol Res Ctr Tabriz Iran Tabriz Univ Med Sci Mol Med Res Ctr Tabriz Iran Tabriz Univ Med Sci Drug Appl Res Ctr Tabriz Iran 

出 版 物：《JOURNAL OF CELLULAR PHYSIOLOGY》 (细胞生理学杂志)

年 卷 期：2019年第234卷第4期

页      面：3216-3230页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071003[理学-生理学] 

主　　题：epigenetics leukemia non coding RNA 

摘      要：Acute lymphoblastic leukemia (ALL), one of the most common malignant human disorders, originates in different important genetic lesions in T-cell or B-cell progenitors. ALL is a malignant lymphoid progenitor with peak prevalence in children (2-5 years). The rate of survival when one is suffering from ALL depends on various agents including the age of the patient, responses to anti-leukemic therapy, and cell biology. miRNAs and epigenetics are important regulatory factors in the expression of genes. miRNAs are noncoding RNA with inhibitory effectors on specific mRNA. Patterns of DNA methylation are profoundly changed in ALL by epigenetic mechanisms. The deciphering of miRNA and the epigenetic pathogenesis in ALL could revolutionize response to the therapy and outcome, and create an enormous promise for novel approaches to reduce the toxic side-effects of intensive leukemia. Hence, pathogenetic miRNAs and epigenetics leading to the initiation and the progression of ALL are summarized in this review.