Cation-Π Interactions in Biochemistry: A Primer

作     者：Mitchell, Miguel O. Means, John 

作者机构：Amer Inst Res 1000 Thomas Jefferson St NW Washington DC 20007 USA Univ Rio Grande Sch Math & Nat Sci POB 500 Rio Grande OH 45674 USA 

出 版 物：《JOURNAL OF CHEMICAL EDUCATION》 (化学教育杂志)

年 卷 期：2018年第95卷第12期

页      面：2284-2288页

核心收录：

学科分类：0401[教育学-教育学] 07[理学] 0703[理学-化学] 

主　　题：Upper-Division Undergraduate Biochemistry Biophysical Chemistry Molecular Biology Internet/Web-Based Learning Problem Solving/Decision Making Inquiry-Based/Discovery Learning Noncovalent Interactions Molecular Modeling 

摘      要：Although the potent effects of cation-pi interactions for stabilizing protein structure and binding ligands to proteins have been reported in the chemical literature for over two decades, there are no undergraduate biochemistry textbooks covering this important noncovalent attractive force. In an attempt to remedy this situation, this primer describes what cation-pi interactions are, provides biochemical examples of cation-pi interactions that supplement the protein structure and ligand binding topics of a traditional one-semester biochemistry course, and offers exercises and worked out solutions on cation-pi interactions derived from the biochemical literature. In addition, instructions are provided for using the online molecular visualization tools FirstGlance and JSmol viewer to identify cation-pi interactions in proteins and for calculating cation-pi stabilization energy with the online CaPTURE program.