Clinical Comparison of Dose Calculation Using the Enhanced Collapsed Cone Algorithm vs. a New Monte Carlo Algorithm

作     者：Fotina, Irina Kragl, Gabriele Kroupa, Bernhard Trausmuth, Robert Georg, Dietmar 

作者机构：Med Univ Vienna Dept Radiotherapy Div Med Radiat Phys AKH Wien A-1090 Vienna Austria 

出 版 物：《STRAHLENTHERAPIE UND ONKOLOGIE》 (放射疗法与肿瘤学)

年 卷 期：2011年第187卷第7期

页      面：433-441页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 1009[医学-特种医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Austrian National Bank 

主　　题：Dose calculation Monte Carlo Collapsed cone algorithm IMRT 

摘      要：Comparison of the dosimetric accuracy of the enhanced collapsed cone (eCC) algorithm with the commercially available Monte Carlo (MC) dose calculation for complex treatment techniques. A total of 8 intensity-modulated radiotherapy (IMRT) and 2 stereotactic body radiotherapy (SBRT) lung cases were calculated with eCC and MC algorithms with the treatment planning systems (TPS) Oncentra MasterPlan 3.2 (Nucletron) and Monaco 2.01 (Elekta/CMS). Fluence optimization as well as sequencing of IMRT plans was primarily performed using Monaco. Dose prediction errors were calculated using MC as reference. The dose-volume histrogram (DVH) analysis was complemented with 2D and 3D gamma evaluation. Both algorithms were compared to measurements using the Delta4 system (Scandidos). Recalculated with eCC IMRT plans resulted in lower planned target volume (PTV) coverage, as well as in lower organs-at-risk (OAR) doses up to 8%. Small deviations between MC and eCC in PTV dose (1-2%) were detected for IMRT cases, while larger deviations were observed for SBRT (up to 5%). Conformity indices of both calculations were similar;however, the homogeneity of the eCC calculated plans was slightly better. Delta4 measurements confirmed high dosimetric accuracy of both TPS. Mean dose prediction errors 3% for PTV suggest that both algorithms enable highly accurate dose calculations under clinical conditions. However, users should be aware of slightly underestimated OAR doses using the eCC algorithm.