Noncoding RNAs in Alzheimer's disease

作     者：Idda, M. Laura Munk, Rachel Abdelmohsen, Kotb Gorospe, Myriam 

作者机构：NIA Lab Genet & Genom Intramural Res Program NIH 251 Bayview Blvd Baltimore MD 21224 USA 

出 版 物：《WILEY INTERDISCIPLINARY REVIEWS-RNA》 (威立跨学科评论：核糖核酸)

年 卷 期：2018年第9卷第2期

页      面：e1463页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：National Institute on Aging Intramural Research Program  National Institutes of Health 

主　　题：amyloid plaques circRNA lncRNA miRNA neurodegeneration neurofibrillary tangles noncoding RNA posttranscriptional gene regulation 

摘      要：Alzheimer s disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to develop drugs for preventing and treating AD, no effective therapies are available as yet, posing a growing burden at the personal, medical, and socioeconomic levels. AD is characterized by the production and aggregation of amyloid beta (A beta) peptides derived from amyloid precursor protein (APP), the presence of hyperphosphorylated microtubule-associated protein Tau (MAPT), and chronic inflammation leading to neuronal loss. A beta accumulation and hyperphosphorylated Tau are responsible for the main histopathological features of AD, A beta plaques, and neurofibrillary tangles (NFTs), respectively. However, the full spectrum of molecular factors that contribute to AD pathogenesis is not known. Noncoding (nc)RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate gene expression at the transcriptional and posttranscriptional levels in various diseases, serving as biomarkers and potential therapeutic targets. There is rising recognition that ncRNAs have been implicated in both the onset and pathogenesis of AD. Here, we review the ncRNAs implicated posttranscriptionally in the main AD pathways and discuss the growing interest in targeting regulatory ncRNAs therapeutically to combat AD pathology. This article is categorized under: RNA in Disease and Development RNA in Disease